Wissenschaftliche Publikationen

Aus der MAS-Studie ist eine Vielzahl wissenschaftlicher Publikationen hervorgegangen. Hier finden Sie sie alle.

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Publikationen der MAS-Studie

  • Keller, T., et al., The sex-shift in single disease and multimorbid asthma and rhinitis during puberty - a study by MeDALL. Allergy. 2018. 73:602–614.
  • Huang, X., et al., Evolution of the IgE and IgG repertoire to a comprehensive array of allergen molecules in the first decade of life. Allergy 2018. 73(2): p. 421-430.
  • Ferreira, MA, et al. Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. Nat Genet 49, 1752-1757 (2017).
  • Posa, D., et al, Evolution and predictive value of IgE responses toward a comprehensive panel of house dust mite allergens during the first 2 decades of life. J Allergy Clin Immunol. 2017. 2:541-549.
  • Hose, AJ, et al, MAS; PASTURE study groups. Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts. J Allergy Clin Immunol. 2017 Jun. 139(6):1935-1945.e12.
  • Ullemar, V., et al. Heritability and confirmation of genetic association studies for childhood asthma in twins. Allergy 71, 230-238 (2016).
  • Schwarz, A., et al., IgG and IgG4 to 91 allergenic molecules in early childhood by route of exposure and current and future IgE sensitization: Results from the Multicentre Allergy Study birth cohort. J Allergy Clin Immunol. 2016. 138:1426-1433.
  • Grabenhenrich, L.B., et al., Prediction and prevention of allergic rhinitis: A birth cohort study of 20 years. J Allergy Clin Immunol, 2015. 136(4): p. 932-40.e12.
  • Gough, H., et al., Allergic multimorbidity of asthma, rhinitis and eczema over 20 years in the German birth c ohort MAS. Pediatr Allergy Immunol, 2015. 26(5): p. 431-7.
  • Casas, L., et al., Early-life house dust mite allergens, childhood mite sensitization, and respiratory outcomes. Allergy, 2015. 70(7): p. 820-7.
  • Hofmaier, S., et al., “Default” versus “pre-atopic” IgG responses to foodborne and airborne pathogenesis-related group 10 protein molecules in birch-sensitized and nonatopic children. J Allergy Clin Immunol. 2015. 135:1367-1374.
  • Paternoster, L., et al. Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nat Genet 47, 1449-1456 (2015).
  • Marenholz, I., et al. Meta-analysis identifies seven susceptibility loci involved in the atopic march. Nat Commun 6, 8804 (2015).
  • Esparza-Gordillo. J., et al. Maternal filaggrin mutations increase the risk of atopic dermatitis in children: an effect independent of mutation inheritance. PLoS genetics 11, e1005076 (2015).
  • Grabenhenrich, L.B., et al., Early-life determinants of asthma from birth to age 20 years: a German birth cohort study. J Allergy Clin Immunol, 2014. 133(4): p. 979-88.
  • Grabenhenrich, L.B., et al., The novel 10-item asthma prediction tool: external validation in the German MAS birth cohort. PLoS One, 2014. 9(12): p. e115852.
  • Hatzler, L., Parental hay fever reinforces IgE to pollen as pre-clinical biomarker of hay fever in childhood. Pediatr Allergy Immunol 2014. 25:366-73.
  • Hohmann, C., et al., The development of the MeDALL Core Questionnaires for a harmonized follow-up assessment of eleven European birth cohorts on asthma and allergies. Int Arch Allergy Immunol, 2014. 163(3): p. 215-24.
  • Matricardi, PM. Allergen-specific immunoprophylaxis: toward secondary prevention of allergic rhinitis? Pediatr Allergy Immunol 2014. 25:15-8.
  • Pinart, M. et al., Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: a population-based cohort study. Lancet Respir Med. 2014 Feb. 2(2):131-40.
  • Scholtens, S., et al. Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure. J Allergy Clin Immunol 133, 885-888 (2014).
  • Esparza-Gordillo, J., et al., A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis. J Allergy Clin Immunol, 2013. 132(2): p. 371-7.
  • Melen, E, et al. Genome-wide association study of body mass index in 23 000 individuals with and without asthma. Clin Exp Allergy 43, 463-474 (2013).
  • Rzehak, P., et al., Body mass index trajectory classes and incident asthma in childhood: results from 8 European Birth Cohorts--a Global Allergy and Asthma European Network initiative. J Allergy Clin Immunol, 2013. 131(6): p. 1528-36.
  • Hatzler, L., et al. Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever. J Allergy Clin Immunol. 2012.130:894-901.e5.
  • Lødrup Carlsen, KC, et al., GALEN WP 1.5 ‘Birth Cohorts’ working group. Does pet ownership in infancy lead to asthma or allergy at school age? Pooled analysis of individual participant data from 11 European birth cohorts. PLoS One. 2012. 7(8):e43214.
  • Neuman, Å., et al. ENRIECO Consortium. Maternal smoking in pregnancy and asthma in preschool children: a pooled analysis of eight birth cohorts. Am J Respir Crit Care Med. 2012 Nov 15;186(10):1037-43.
  • Marenholz, I., et al. The eczema risk variant on chromosome 11q13 (rs7927894) in the population-based ALSPAC cohort: a novel susceptibility factor for asthma and hay fever. Hum Mol Genet 20, 2443-2449 (2011).
  • Rochat, M.K., et al., Allergic rhinitis as a predictor for wheezing onset in school-aged children. J Allergy Clin Immunol, 2010. 126(6): p. 1170-5.e2.
  • Keil, T., et al., Maternal smoking increases risk of allergic sensitization and wheezing only in children with allergic predisposition: longitudinal analysis from birth to 10 years. Allergy, 2009. 64(3): p. 445-51.
  • Marenholz, I., et al., An interaction between filaggrin mutations and early food sensitization improves the prediction of childhood asthma. J Allergy Clin Immunol, 2009. 123(4): p. 911-6.
  • Matricardi, P.M., et al., Longitudinal trends of total and allergen-specific IgE throughout childhood. Allergy, 2009. 64(7): p. 1093-8.
  • Matricardi, P.M., et al., Dynamic evolution of serum immunoglobulin E to airborne allergens throughout childhood: results from the Multi-Centre Allergy Study birth cohort. Clin Exp Allergy, 2009. 39(10): p. 1551-7.
  • Bockelbrink, A., et al., Environmental noise and asthma in children: sex-specific differences. J Asthma, 2008. 45(9): p. 770-3.
  • Grüber, C., et al., History of respiratory infections in the first 12 yr among children from a birth cohort. Pediatr Allergy Immunol, 2008. 19(6): p. 505-12.
  • Karaolis-Danckert, N., et al., How pre- and postnatal risk factors modify the effect of rapid weight gain in infancy and early childhood on subsequent fat mass development: results from the Multicenter Allergy Study 90. Am J Clin Nutr, 2008. 87(5): p. 1356-64.
  • Matricardi, P.M., et al., Wheezing in childhood: incidence, longitudinal patterns and factors predicting persistence. Eur Respir J, 2008. 32(3): p. 585-92.
  • Müller, S., et al., MBL2 variants in relation to common childhood infections and atopy-related phenotypes in a large German birth cohort. Pediatr Allergy Immunol, 2007. 18(8): p. 665-70.
  • Schulz, F., et al., A common haplotype of the IL-31 gene influencing gene expression is associated with nonatopic eczema. J Allergy Clin Immunol, 2007. 120(5): p. 1097-102.
  • Bierbaum, S., et al., Confirmation of association of IL-15 with pediatric asthma and comparison of different controls. Allergy, 2006. 61(5): p. 576-80.
  • Illi, S., et al., Perennial allergen sensitisation early in life and chronic asthma in children: a birth cohort study. Lancet, 2006. 368(9537): p. 763-70.
  • Marenholz, I., et al., Filaggrin loss-of-function mutations predispose to phenotypes involved in the atopic march. J Allergy Clin Immunol, 2006. 118(4): p. 866-71.
  • Keil, T., et al., Working Group of GA2LEN-WP 1.5 'Birth Cohorts'. European birth cohort studies on asthma and atopic diseases: I. Comparison of study designs - a GA2LEN initiative. Allergy 2006 Feb. 61(2):221-8.
  • Keil, T., et al., working group of GA2LEN-WP 1.5 Birth Cohorts. European birth cohort studies on asthma and atopic diseases: II. Comparison of outcomes and exposures - a GA2LEN initiative. Allergy 2006 Sep. 61(9):1104-11.
  • Schedel, M., et al., The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations. Respir Res, 2006. 7: p. 91.
  • Deindl, P., et al., No association of histamine- N-methyltransferase polymorphism with asthma or bronchial hyperresponsiveness in two German pediatric populations. Pediatr Allergy Immunol, 2005. 16(1): p. 40-2.
  • Lau, S., et al., Longitudinal study on the relationship between cat allergen and endotoxin exposure, sensitization, cat-specific IgG and development of asthma in childhood--report of the German Multicentre Allergy Study (MAS 90). Allergy, 2005. 60(6): p. 766-73.
  • Nickel, R., et al., Association study of Glutathione S-transferase P1 (GSTP1) with asthma and bronchial hyper-responsiveness in two German pediatric populations. Pediatr Allergy Immunol, 2005. 16(6): p. 539-41.
  • Nickel, R., et al., Variability of total serum immunoglobulin E levels from birth to the age of 10 years. A prospective evaluation in a large birth cohort (German Multicenter Allergy Study). Clin Exp Allergy, 2005. 35(5): p. 619-23.
  • Söderhäll, C., et al., Lack of association of the G protein-coupled receptor for asthma susceptibility gene with atopic dermatitis. J Allergy Clin Immunol, 2005. 116(1): p. 220-1.
  • Illi, S., et al., The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol, 2004. 113(5): p. 925-31.
  • Liu, X., et al., Associations between specific serum IgE response and 6 variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study. J Allergy Clin Immunol, 2004. 113(3): p. 489-95.
  • Bergmann, K.E., et al., Early determinants of childhood overweight and adiposity in a birth cohort study: role of breast-feeding. Int J Obes Relat Metab Disord, 2003. 27(2): p. 162-72.
  • Grüber, C., et al., Transient suppression of atopy in early childhood is associated with high vaccination coverage. Pediatrics, 2003. 111(3): p. e282-8.
  • Liu, X., et al., Associations between total serum IgE levels and the 6 potentially functional variants within the genes IL4, IL13, and IL4RA in German children: the German Multicenter Atopy Study. J Allergy Clin Immunol, 2003. 112(2): p. 382-8.
  • Sengler, C., et al., Evaluation of the CD14 C-159 T polymorphism in the German Multicenter Allergy Study cohort. Clin Exp Allergy, 2003. 33(2): p. 166-9.
  • Sengler, C., et al., Clara cell protein 16 (CC16) gene polymorphism influences the degree of airway responsiveness in asthmatic children. J Allergy Clin Immunol, 2003. 111(3): p. 515-9.
  • Weinmann, S., et al., The costs of atopy and asthma in children: assessment of direct costs and their determinants in a birth cohort. Pediatr Allergy Immunol, 2003. 14(1): p. 18-26.
  • Bergmann, R.L., et al., Breastfeeding duration is a risk factor for atopic eczema. Clin Exp Allergy, 2002. 32(2): p. 205-9.
  • Lau, S., et al., The development of childhood asthma: lessons from the German Multicentre Allergy Study (MAS). Paediatr Respir Rev, 2002. 3(3): p. 265-72.
  • Nickel, R., et al., Messages from the German Multicentre Allergy Study. Pediatr Allergy Immunol, 2002. 13 Suppl 15: p. 7-10.
  • Nickel, R., et al., Comparison of bronchial responsiveness to histamine in asthma, allergic rhinitis and allergic sensitization at the age of 7 years. Clin Exp Allergy, 2002. 32(9): p. 1274-7.
  • Nickel, R., et al., How should a birth cohort study be organised? Experience from the German MAS cohort study. Paediatr Respir Rev, 2002. 3(3): p. 169-76.
  • Grüber, C., et al., Delayed hypersensitivity to tuberculin, total immunoglobulin E, specific sensitization, and atopic manifestation in longitudinally followed early Bacille Calmette-Guérin-vaccinated and nonvaccinated children. Pediatrics, 2001. 107(3): p. E36.
  • Grüber, C., et al., Down-regulation of IgE and IgG4 antibodies to tetanus toxoid and diphtheria toxoid by covaccination with cellular Bordetella pertussis vaccine. J Immunol, 2001. 167(4): p. 2411-7.
  • Illi, S., et al., Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study. BMJ, 2001. 322(7283): p. 390-5.
  • Illi, S., et al., The pattern of atopic sensitization is associated with the development of asthma in childhood. J Allergy Clin Immunol, 2001. 108(5): p. 709-14.
  • Niggemann, B., et al., Histamine challenges discriminate between symptomatic and asymptomatic children. MAS-Study Group. Multicentre Allergy Study. Eur Respir J, 2001. 17(2): p. 246-53.
  • Wahn, U. and E. von Mutius, Childhood risk factors for atopy and the importance of early intervention. J Allergy Clin Immunol, 2001. 107(4): p. 567-74.
  • Bergmann, R.L., et al., Socioeconomic status is a risk factor for allergy in parents but not in their children. Clin Exp Allergy, 2000. 30(12): p. 1740-5.
  • Beyer, K., et al., Association and linkage of atopic dermatitis with chromosome 13q12-14 and 5q31-33 markers. J Invest Dermatol, 2000. 115(5): p. 906-8.
  • Kulig, M., et al., Does allergy in parents depend on allergy in their children? Recall bias in parental questioning of atopic diseases. Multicenter Allergy Study Group. J Allergy Clin Immunol, 2000. 105(2 Pt 1): p. 274-8.
  • Kulig, M., et al., Development of seasonal allergic rhinitis during the first 7 years of life. J Allergy Clin Immunol, 2000. 106(5): p. 832-9.
  • Lau, S., et al., Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study. Multicentre Allergy Study Group. Lancet, 2000. 356(9239): p. 1392-7.
  • Lee, Y.A., et al., A major susceptibility locus for atopic dermatitis maps to chromosome 3q21. Nat Genet, 2000. 26(4): p. 470-3.
  • Liu, X., et al., An IL13 coding region variant is associated with a high total serum IgE level and atopic dermatitis in the German multicenter atopy study (MAS-90). J Allergy Clin Immunol, 2000. 106(1 Pt 1): p. 167-70.
  • Nickel, R.G., et al., Atopic dermatitis is associated with a functional mutation in the promoter of the C-C chemokine RANTES. J Immunol, 2000. 164(3): p. 1612-6.
  • Kulig, M., et al., Natural course of sensitization to food and inhalant allergens during the first 6 years of life. J Allergy Clin Immunol, 1999. 103(6): p. 1173-9.
  • Kulig, M., et al., Effect of pre- and postnatal tobacco smoke exposure on specific sensitization to food and inhalant allergens during the first 3 years of life. Multicenter Allergy Study Group, Germany. Allergy, 1999. 54(3): p. 220-8.
  • Kulig, M., W. Luck, and U. Wahn, The association between pre- and postnatal tobacco smoke exposure and allergic sensitization during early childhood. Multicentre Allergy Study Group, Germany. Hum Exp Toxicol, 1999. 18(4): p. 241-4.
  • Kulig, M., et al., Serum IgE levels during the first 6 years of life. J Pediatr, 1999. 134(4): p. 453-8.
  • Nickel, R., et al., Genetic markers of atopy in infancy: results from the German Multicenter Allergy Study. Clin Exp Allergy, 1999. 29 Suppl 4: p. 23-5.
  • Bergmann, R.L., K.E. Bergmann, and U. Wahn, Can we predict atopic disease using perinatal risk factors? Clin Exp Allergy, 1998. 28(8): p. 905-7.
  • Bergmann, R.L., et al., Atopic dermatitis in early infancy predicts allergic airway disease at 5 years. Clin Exp Allergy, 1998. 28(8): p. 965-70.
  • Edenharter, G., et al., Cord blood-IgE as risk factor and predictor for atopic diseases. Clin Exp Allergy, 1998. 28(6): p. 671-8.
  • Kulig, M., et al., Prediction of sensitization to inhalant allergens in childhood: evaluating family history, atopic dermatitis and sensitization to food allergens. The MAS Study Group. Multicentre Allergy Study. Clin Exp Allergy, 1998. 28(11): p. 1397-403.
  • Kulig, M., et al., Long-lasting sensitization to food during the first two years precedes allergic airway disease. The MAS Study Group, Germany. Pediatr Allergy Immunol, 1998. 9(2): p. 61-7.
  • Niggemann, B., et al., Development of latex allergy in children up to 5 years of age--a retrospective analysis of risk factors. Pediatr Allergy Immunol, 1998. 9(1): p. 36-9.
  • Bergmann, R.L., et al., Predictability of early atopy by cord blood-IgE and parental history. Clin Exp Allergy, 1997. 27(7): p. 752-60.
  • Nickel, R., et al., Evidence for linkage of chromosome 12q15-q24.1 markers to high total serum IgE concentrations in children of the German Multicenter Allergy Study. Genomics, 1997. 46(1): p. 159-62.
  • Wahn, U., et al., The natural course of sensitisation and atopic disease in infancy and childhood. Pediatr Allergy Immunol, 1997. 8(10 Suppl): p. 16-20.
  • Wahn, U., et al., Indoor allergen exposure is a risk factor for sensitization during the first three years of life. J Allergy Clin Immunol, 1997. 99(6 Pt 1): p. 763-9.
  • Dannemann, A., et al., Specific IgE and IgG4 immune responses to tetanus and diphtheria toxoid in atopic and nonatopic children during the first two years of life. Int Arch Allergy Immunol, 1996. 111(3): p. 262-7.
  • Forster, J., et al., Respiratory syncytial virus infection: its role in aeroallergen sensitization during the first two years of life. Pediatr Allergy Immunol, 1996. 7(2): p. 55-60.
  • Bergmann, R.L., et al., Determinants of cord-blood IgE concentrations in 6401 German neonates. Allergy, 1995. 50(1): p. 65-71.
  • Bergmann, R.L., et al., Atopic diseases in infancy. The German multicenter atopy study (MAS-90). Pediatr Allergy Immunol, 1994. 5(6 Suppl): p. 19-25.
  • Bergmann, R.L., et al., Atopic family history. Validation of instruments in a multicenter cohort study. Pediatr Allergy Immunol, 1993. 4(3): p. 130-5.
  • Bujanowski-Weber, J., et al., Analysis of IgE-binding factors (sCD23) within newborn sera. Int Arch Allergy Immunol, 1992. 99(1): p. 127-32.
  • Bergmann, K.E., et al., Prediction of atopic disease in the newborn: methodological aspects. Clin Exp Allergy, 1990. 20 Suppl 3: p. 21-6.