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Selected Publications of the Naturopathy and Integrative Medicine Research Group

Here you will find important publications from the Naturopathy and Integrative Medicine Research Unit of the Institute of Social Medicine, Epidemiology and Health Economics at the Charité - Universitätsmedizin Berlin.

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  • Ortiz M, Koch AK, Cramer H, Linde K, Rotter G, Teut M, Brinkhaus B, Haller H. Clinical effects of Kneipp hydrotherapy: a systematic review of randomised controlled trials. BMJ Open. 2023 Jul 9;13(7):e070951. doi: 10.1136/bmjopen-2022-070951. PMID: 37423627; PMCID: PMC10335435.
  • Kubasch J, Ortiz M, Binting S, King R, Dietzel J, Nögel R, Hummelsberger J, Willich SN, Brinkhaus B, Teut M, Siewert J. Hydrotherapy and acupressure in restless legs syndrome: A randomized, controlled, 3-armed, explorative clinical trial. Medicine (Baltimore). 2023 Jun 30;102(26):e34046. doi: 10.1097/MD.0000000000034046. PMID: 37390284; PMCID: PMC10313283.
  • Dietzel J, Habermann IV, Hörder S, Hahn K, Meyer-Hamme G, Ortiz M, Hua K, Stöckigt B, Bolster M, Grabowska W, Roll S, Binting S, Willich SN, Schröder S, Brinkhaus B. Acupuncture in Patients with Diabetic Peripheral Neuropathy-Related Complaints: A Randomized Controlled Clinical Trial. J Clin Med. 2023 Mar 7;12(6):2103. doi: 10.3390/jcm12062103. PMID: 36983105; PMCID: PMC10055667.
  • Jeserich F, Klein C, Brinkhaus B, Teut M. Sense of coherence and religion/spirituality: A systematic review and meta-analysis based on a methodical classification of instruments measuring religion/spirituality. PLoS One. 2023 Aug 3;18(8):e0289203. doi: 10.1371/journal.pone.0289203. PMID: 37535597; PMCID: PMC10399782.
  • Rotter G, Binting S, Teut M, Ortiz M, Willich SN, Brinkhaus B. Characteristics of Patients Presenting at a University Outpatient Department for Complementary and Integrative Medicine. Complement Med Res. 2023;30(4):279-288. English. doi: 10.1159/000529798. Epub 2023 Feb 20. PMID: 36804827.
  • Rotter G, Teut M, Schleicher R, Dell'Oro M, Ortiz M, Binting S, Tissen-Diabaté T, Roll S, Michalsen A, Staab D, Wolfarth B, Brinkhaus B. Hypnotherapy, Intermittent Fasting, and Exercise Group Programs in Atopic Dermatitis: A Randomized Controlled Explorative Clinical Trial During the COVID-19 Pandemic. J Integr Complement Med. 2023 Feb;29(2):99-110. doi: 10.1089/jicm.2022.0699. Epub 2022 Nov 25. PMID: 36450119; PMCID: PMC9942184.
  • Jeitler M, Erehman A, Koppold DA, Ortiz M, Jerzynski L, Stöckigt B, Rotter G, Blakeslee S, Brinkhaus B, Michalsen A, Seifert G, Cramer H, Kandil FI, Kessler CS. Self-care and lifestyle interventions of complementary and integrative medicine during the COVID-19 pandemic-A cross-sectional study. Front Med (Lausanne). 2023 Jan 9;9:1033181. doi: 10.3389/fmed.2022.1033181. PMID: 36698795; PMCID: PMC9868272.


  • Bringmann HC, Michalsen A, Jeitler M, Kessler CS, Brinkhaus B, Brunnhuber S, Sedlmeier P. Meditation-based lifestyle modification in mild to moderate depression - A randomized controlled trial. Depress Anxiety. 2022;39(5):363-375. doi: 10.1002/da.23249.
  • Schröder ML, Stoeckigt B, Binting S, Tissen-Diabeté T, Bangemann N, Goerling U, Kröz M, Blohmer JU, Ortiz M, Brinkhaus B. Feasibility and Possible Effects of Mindful Walking and Moderate Walking in Breast Cancer Survivors: A Randomized Controlled Pilot Study With a Nested Qualitative Study Part. Integr Cancer Ther. 2022; doi: 10.1177/15347354211066067.
  • Rotter G, Teut M, Binting S, Michalsen A, Ortiz M, Brinkhaus B. Lifestyle Behaviors in Patients with Atopic Dermatitis - Results of a Cross-sectional Study following a Randomized Controlled Trial. Complement Med Res. 2022; doi: 10.1159/000527107. Online ahead of print.
  • Rotter G, Ahnert MW, Geue AV, Icke K, Binting S, Tissen-Diabeté T, Roll S, Ortiz M, Reinhold T, Kass B, Staab D, Pfab F, Willich SN, Brinkhaus B. Acupuncture and Osteopathic Medicine for Atopic Dermatitis - a Three-armed Randomized Controlled Explorative Clinical Trial. Clin Exp Dermatol. 2022; doi: 10.1111/ced.15340. Online ahead of print..
  • Jerzynski L, Rotter G, Binting S, Teut M, Tissen-Diabaté T, Jeitler M, Seifert G, Kessler C, Michalsen A, Cramer H, Stoeckigt B, Brinkhaus B, Ortiz M. Health-related Self-Care Strategies and Coping Resources During the COVID-19 Pandemic: An Online-Based Cross-Sectional Study. J Integr Complement Med. 2022;28(10):799-810. doi: 10.1089/jicm.2022.0475.
  • Rotter G, Ortiz M, Binting S, Tomzik J, Reese F, Roll S, Brinkhaus B, Teut M. Mindful Walking in Patients with Chronic Low Back Pain: A Randomized Controlled Trial. J Integr Complement Med. 2022;28(6):474-483. doi: 10.1089/jicm.2021.0361.


  • Dietzel J, Hörder S, Habermann IV, Meyer-Hamme G, Hahn K, Ortiz M, Roll S, Linde K, Irnich D, Hammes M, Nögel R, Wullinger M, Wortmann V, Hummelsberger J, Willich SN, Schröder S, Brinkhaus B. Acupuncture in diabetes peripheral neuropathy-protocol for the randomized, multicenter ACUDPN trial. Trials. 2021;22(1):164.doi: 10.1186/s13063-021-05110-1.
  • Rotter G, Binting S, Tissen-Diabaté T, Ortiz M, Brinkhaus B. Osteopathic Medicine in Four Chronic Musculosketal Pain Diseases: An Observational Trial with Follow-Up. Coplement Med Res. 2021. doi: 10.1159/000518311. Online ahead of print.
  • Rotter G, Jerzynski L, Hinse M, Binting S, Brinkhaus B. The Attitude of Medical Students Toward Complementary Medicine: Results of a Cross-Sectional Study. J Altern Complement Med. 2021. doi: 10.1089/acm.2021.0181. Online ahead of print.
  • Rotter G, Schollbach L, Binting S, Dornquast C, Scherr J, Pfab F, Brinkhaus B. Use of Complementary Medicine in Competitive Sports: Results of a Cross-Sectional Study. 2021;28(2):139-145. doi: 10.1159/000511247. Epub 2020 Nov 4.
  • Stoeckigt B, Jeserich F, Walach H, Elies M, Brinkhaus B, Teut M. Experiences and Perceived Effects of Rosary Praying: A Qualitative Study. J Relig Health. 2021;60(6):3886-3906. doi: 10.1007/s10943-021-01299-2. Epub 2021 Jun 9.


  • Brinkhaus B, Ortiz M, Dietzel J, Willich SN. Acupuncture for pain and allergic rhinitis-from clinical experience to evidence. Bundesgesundheitsblatt. 2020;63(5): 561-569. doi: 10.1007/s00103-020-03127-6.
  • Cramer H, Klose P, Teut M, Rotter G, Ortiz M, Anheyer D, Linde K, Brinkhaus B. Cupping for patients with chronic pain: A systematic review and meta-analysis. J Pain. 2020; doi: 10.1016/j.jpain.2020.01.002.
  • Kiepe MS, Fernholz I, Schmidt T, Brinkhaus B, Schmidt A, Weikert C, Rotter G. Effects of osteopathic manipulative treatment on musicians: a systematic review. Med Probl Perform Art. 2020; 35(2): 110-115. doi: 10.21091/mppa.2020.2017.
  • Fisch S, Binting S, Roll S, Cree M, Brinkhaus B, Teut M. Group hypnosis for stress reduction - a feasibility study. Int J Clin Exp Hypn. 2020; 68(4): 493-510. doi: 10.1080/00207144.2020.1781537.


  • Brinkhaus B, Kirschbaum B, Stöckigt B, Binting S, Roll S, Carstensen M, Witt CM. Prophylactic acupuncture treatment during chemotherapy with breast cancer: a randomized pragmatic trial with a retrospective nested qualitative study. Breast Cancer Res Treat. 2019; 178(3): 617-628.
  • Adam D, Keller T, Mühlbacher A, Hinse M, Icke K, Teut M, Brinkhaus B, Reinhold T. The value of treatment processes in Germany: a discrete choice experiment on patient preferences in complementary and conventional medicine.Patient. 2019: 12(3): 349-360.
  • Stöckigt B, Suhr R, Sulmann D, Teut M, Brinkhaus B. Implementation of Intentional Touch for Geriatric Patients with Chronic Pain: A Qualitative Pilot Study. Complement Med Res. 2019;26(3):195-205. doi: 10.1159/000496063. Epub 2019 Apr 3.
  • Ortiz M, Schnabel K, Binting S, Fischer HF, Teut M, Suhr R, Brinkhaus B. Complementary and integrative medicine in nursing homes: results of a cross-sectional study in residents and caregivers. Complement Med Res. 2019; 26(5): 310-321. doi: 10.1159/000500515.


  • Adam D, Grabenhenrich L, Ortiz M, Binting S, Reinhold T, Brinkhaus B. Impact of acupuncture on antihistamine use in patients suffering seasonal allergic rhinitis: secondary analysis of results from a randomised controlled trial. Acupunct Med. 2018;doi:10.1136/acupmed-2017-011382.


  • Fisch F, Brinkhaus B, Teut M. Hypnosis in patients with peceived stress - a systematic review. BMC CAM. 2017;doi: 10.1186s/12906-017-1806-0.
  • Linde K, Brinkhaus B. Randomized Trials of Chinese Herbal Medicine: A new extension of the CONSORT Statement. Ann Intern Med. 2017;doi: 10.7326/M17-1067.
  • Rotter G, Brinkhaus B. Osteopathic treatment of gastroesophegeal reflux disease and hiatal hernia: a case report following the CARE guideline. Complement Med Res. 2017;24:1-5.


  • Linde K, Allais G, Brinkhaus B, Fei Y, Mehring M, Vertosick EA, Vickers A, White AR. Acupuncture for the prevention of episodic migraine. Cochrane Database Syst Rev. 2016: doi 10.1002/14651858.CD001218.pub3.
  • Linde K, Allais G, Brinkhaus B, Fei Y, Mehring M, Vertosick EA, Vickers A, White AR. Acupuncture for the prevention of tension-type headache. Cochrane Database Syst Rev. 2016: doi 10.1002/14651858.CD007587.pub2.


  • Ortiz M, Brinkhaus B, Enck P, Musial F, Zimmermann-Viehoff F. Autonomic Function in Seasonal Allergic Rhinitis and Acupuncture -  an Experimental Pilot Study within a Randomized Trial. Forsch Komplementmed, 2015;22:85-92.


  • Ortiz M, Witt CM, Binting S, Helmreich C, Hummelsberger J, Pfab F, Wullinger M, Irnich D, Linde K, Niggemann B, Willich SN, Brinkhaus B. A randomised multicentre trial of acupuncture in patients with seasonal allergic rhinitis - trial intervention including physician and treatment characteristics. BMC Complement Altern Med 2014;14(1):128.
  • Fischer F, Lewith G, Witt CM, Linde K, von Ammon K, Cardini F, Falkenberg T, Fønnebø V, Johannessen H, Reiter B, Uehleke B, Weidenhammer W, Brinkhaus B. [A research roadmap for complementary and alternative medicine - what we need to know by 2020]. Forsch Komplementmed 2014;21(2):e1-16.
  • Ortiz M, Soom Ammann E, Salis Gross C , Schnabel K, Walbaum T, Binting S, Fischer HF, Teut M, Kottner J, Brinkhaus B. Complementary Medicine in Nursing Homes - Results of a Mixed Methods Pilot Study. BMC Complement Altern Med 2014:14:443.


  • Teut M, Roesner EJ, Ortiz M, Reese F, Binting S, Roll S, Fischer HF, Michalsen A, Willich SN, Brinkhaus B. Mindful walking in psychologically distressed individuals: a randomized controlled trial. Evid Based Complement Alternat Med 2013;2013:489856
  • Brinkhaus B, Ortiz M, Witt C, Roll S, Linde K, Pfab F, Niggemann B, Hummelsberger J, Treszl A, Ring J, Zuberbier T, Wegscheider K, Willich S. Acupuncture in patients with seasonal allergic rhinitis: a randomized trial. Ann Intern Med, 2013;158(4):225-234.
  • Reinhold T, Roll S, Willich SN, Ortiz M, Witt CM, Brinkhaus B. Cost-effectiveness for acupuncture in seasonal allergic rhinitis: economic results of the ACUSAR trial. Ann Allergy Asthma Immunol 2013;111(1):56-63.
  • Kröz M, Fink M, Reif M, Grobbecker S, Zerm R, Quetz M, Frühwirth M, Brinkhaus B, Bartsch C, Girke M, Gutenbrunner C. Multimodal therapy concept and aerobic training in breast cancer patients with chronic cancer-related fatigue. Integr Cancer Ther 2013;12:301-11.


  • Teut M, Kaiser S, Ortiz M, Roll S, Binting S, Willich SN, Brinkhaus B. Pulsatile dry cupping in patients with osteoarthritis of the knee - a randomized controlled exploratory trial. BMC Complement Altern Med 2012;12:184.
  • Holmberg C, Brinkhaus B, Witt C. Experts' opinions on terminology for complementary and integrative medicine - a qualitative study with leading experts. BMC Complement Altern Med 2012;12:218.
  • Eardley S, Bishop FL, Prescott P, Cardini F, Brinkhaus B, Santos-Rey K, Vas J, von Ammon K, Hegyi G, Dragan S, Uehleke B, Fønnebø V, Lewith G. A Systematic Literature Review of Complementary and Alternative Medicine Prevalence in EU. Forsch Komplementmed 2012;19(Suppl. 2):18-28.
    Fischer HF, Junne F, Witt C, von Ammon K, Cardini F, Fønnebø V, Johannessen H, Lewith G, Uehleke B, Weidenhammer W, Brinkhaus B. Key issues in clinical and epidemiological research in complementary and alternative medicine - a systematic literature review. Forsch Komplementmed. 2012;19 (Suppl 2):51-60.
  • Houschyar KS, Lüdtke R, Dobos GJ, Kalus U, Broecker-Preuss M, Rampp T, Brinkhaus B, Michalsen A. Effects of phlebotomy-induced reduction of body iron stores on metabolic syndrome: results from a randomized clinical trial. BMC Med 2012;10:54.
  • Brinkhaus B, Witt C. Making better doctors – using mind-body medicine skills as a self-care element in medical education at the charité university medical school. Forsch Komplementmed 2012;19:4-6.


  • Weidenhammer W, Lewith G, Falkenberg T, Fønnebø V, Johannessen H, Reiter B, Uehleke B, von Ammon K, Baumhöfener F, Brinkhaus B. EU FP7 project 'CAMbrella' to build European research network for complementary and alternative medicine. Forsch Komplementmed 2011;18:69-76.
    Rendant D, Pach D, Luedtke R, Reisshauer A, Mietzner A, Willich S, Witt C. Qigong versus exercise versus no therapy for patients with chronic neck pain: a randomized controlled trial. Spine 2011;36(6):419-427.
  • Brinkhaus B, Witt CM, Jena S, Bockelbrink A, Ortiz M, Willich SN. Integration of complementary and alternative medicine into medical schools in Austria, Germany and Switzerland – results of a cross-sectional study. Wien Med Wochenschr 2011;161:32-43.
  • Brinkhaus B, Lewith G, Rehberg B, Heusser P, Cummings M, Michalsen A, Teut M, Willich SN, Irnich D. How to treat a patient with chronic low back pain – methodology and results of the first international case conference of integrative medicine. Complement Ther Med 2011;19:54-62.
  • Kröz M, Schad F, Reif M, von Laue HB, Feder G, Zerm R, Willich SN, Girke M, Brinkhaus B. Validation of the State Version Questionnaire on Autonomic Regulation (State-aR) for cancer patients. Eur J Med Res 2011;16:457-68.
  • Lechner M, Steirer I, Brinkhaus B, Chen Y, Krist-Dungl C, Koschier A, Gantschacher M, Neumann K, and Zauner-Dungl A. Efficacy of individualized Chinese Herbal Medication in Osteoarthrosis of Hip and Knee - A Double Blind, Randomized-Controlled Clinical Study. J Altern Complement Med 2011;17:539-47.

2010 and earlier

  • Brinkhaus B, Witt CM, Ortiz M, Roll S, Reinhold T, Linde K, Pfab F, Niggemann B, Hummelsberger J, Irnich D, Wegscheider K, Willich SN. Acupuncture in Seasonal Allergic Rhinitis (ACUSAR) – Design and Protocol of a Randomised Controlled Multicenter Trial. Forsch Komplement 2010; 17:95-102.
  • Witt CM, Brinkhaus B. Efficacy, effectiveness and cost-effectiveness of acupuncture for allergic rhinitis – an overview about previous and ongoing studies. Autonomic Neuroscience: Basic and Clinical 2010;157(1-2):42-45.
  • Kiene H; Brinkhaus B, Fischer CG, Girke M, Hahn EG, Hoppe J-D, Jütte R, Klitzsch W, Kraft K, Matthiesen PF, Meister P, Michalsen A, Teut M, Willich SW, Hampel H. Ärztliche Professionalität und Komplementärmedizin: Was ist seriöses Therapieren? Deutsches Ärzteblatt 2010;107:A548-550.
  • Witt CM, Brinkhaus B, Willich SN. Future medical doctors need to be informed about CAM to ensure safe and competent patient care. GMS Z Med Ausbild 2010;27:Doc22.
  • Linde K, Allais G, Brinkhaus B, Manheimer E, Vickers A, White AR. Acupuncture for tension-type headache. Cochrane Database Syst Rev. 2009;CD007587.
  • Brinkhaus B, Witt C, Jena S, Liecker B, Wegscheider K, Willich S. Acupuncture in patients with allergic rhinitis: a pragmatic trial. Ann Allergy Asthma Immunol 2008;101(5):535-543.
  • Brinkhaus B, Witt CM, Jena S, Linde K, Streng A, Wagenpfeil S, Irnich D, Walther HU, Melchart D, Willich SN. Acupuncture in patients with chronic low back pain: a randomized controlled trial. Arch Intern Med 2006;166(4):450-7.
  • Melchart D, Streng A, Hoppe A, Brinkhaus B, Witt C, Wagenpfeil S, Pfaffenrath V, Hammes M, Hummelsberger J, Irnich D, Weidenhammer W, Willich SN, Linde K. Acupuncture in patients with tension-type headache: randomised controlled trial. BMJ 2005;331(7513):736-82.
  • Witt C, Brinkhaus B, Jena S, Linde K, Streng A, Wagenpfeil S, Hummelsberger J, Walther HU, Melchart D, Willich SN. Acupuncture in patients with osteoarthritis of the knee: a randomised trial. Lancet 2005;366(9480):136-43.
  • Linde K, Streng A, Jürgens S, Hoppe A, Brinkhaus B, Witt C, Wagenpfeil S, Pfaffenrath V, Hammes MG, Weidenhammer W, Willich SN, Melchart D. Acupuncture for patients with migraine: a randomized controlled trial. JAMA 2005;293(17):2118-25.