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Selected Publications

Here you will find important publications from the Integrative Medicine and Digital Health Research Group of the Institute of Social Medicine, Epidemiology and Health Economics at the Charité - Universitätsmedizin Berlin.

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  • Pach D, Blödt S, Wang J, Keller T, Bergmann B, Rogge AA, Barth J, Icke K, Roll S, Witt CM. App-Based Relaxation Exercises for Patients with Chronic Neck Pain: Pragmatic Randomized Trial. JMIR MHealth UHealth. 2022;10(1):e31482. doi: 10.2196/31482.
  • Thomae AV, Rogge AA, Helmer SM, Icke K, Witt CM. Development, Implementation, and Evaluation of an e-Learning in Integrative Oncology for Physicians and Students Involving Experts and Learners: Experiences and Recommendations. Journal of Cancer Education. 2022. doi: 10.1007/s13187-022-02189-1.


  • Rogge AA, Helmer SM, King R, Canella C, Icke K, Pach D, Witt CM. Effects of Training Oncology Physicians Advising Patients on Complementary and Integrative Therapies on Patient-Reported Outcomes: A Multicenter, Cluster-Randomized Trial. Cancer. 2021;127(15):2683-2692;
  • Rogge A, Helmer SM, Kiessling C, Witt CM. Development and Implementation of Situational Judgement Tests as an Evaluation Method for Training Oncology Physicians: Application in the KOKON-KTO-Training. JCE. 2021.
  • Heiss A, Wang J, Fei Y, Xia R, Icke K, Pach D, Witt CM. Current practice of stakeholder engagement: researchers' experiences in North America, DACH countries and China. J Comp Eff Res. 2021;
  • Pach D, Rogge AA, Wang J, Witt CM. Five Lessons Learned from Randomized Controlles Trials on Mobile Health Interventions: Consensus Procedure on Practical Recommendations for Sustainable Research. JMIR mHealth Uhealth. 2021;9(2):e20630. doi: 10.2196/20630.
  • Mittring-Junghans N, Holmberg C, Witt CM, Teut M. Thoughts, beliefs and concepts concerning infectious childhood diseases of physicians practicing homeopathic, anthroposophic and conventional medicine - a qualitative study. BMC Complement Med Ther. 2021;21(1):46. doi: 10.1186/s12906-021-03216-2.
  • Stoeckigt B, Kirschbaum B, Carstensen M, Witt CM, Brinkhaus B. Prophylactic Acupuncture Treatment during Chemotherapy in Patients with Breast Cancer - Results of a Qualitative Study nested in a Randomized Pragmatic Trial. Integr Cancer Ther. 2021;20:1-10. doi: 10.117/15347354211058207.


  • Rogge AA, Baur I, Blettner G, Holtkamp U, Horneber M, Jahn P, Joos S, Keberle S, Kettelgerdes A, Klemperer D, Längler A, Voiss P, Weis J, Witt CM. Defining criteria for guiding cancer patients to find a reputable complementary medicine provider: results of a literature review and a consensus procedure. Patient Preference and Adherence. 2020;14:747-755.
  • Witt CM, Helmer SM, Schofield P, Wastell M, Canella C, Thomae AV, Rogge AA. Training oncology physicians to advice their patients on complementary and integrative medicine: an implementation study for a manual-guided consultation. Cancer. 2020;126(13):3031-3041; doi: 10.1002/cncr.32823.
  • Wang J, Rogge AA, Armour M, Smith CA, D'Adamo CR, Pischke CR, Yen HR, Wu MY, Moré AO, Witt CM, Pach D. International ResearchKit App for Women with Menstrual Pain: Development, Access, and Engagement. JMIR mHealth uHealth. 2020;8(2): e14661; doi: 10.2196/14661.


  • Helmer SM, Rogge AA, Fischer F, Pach D, Horneber M, Roll S, Witt CM. Evaluation of a blended learning training concept to train oncology physicians to advise their patients about complementary and integrative medicine (KOKON-KTO): study protocol for a prospective, multi-center, cluster-randomized trial. Trials. 2019;20(1):90.
  • Kessler CS, Morandi A, Kumar A, Dhiman KS, Gupta S, Icke K, Bühner C, Stapelfeldt E, Wischnewsky M, Kronpaß L, Murthy V, Michalsen A, Witt CM. Reliabilty of ayurvedic diagnosis for knee osteoarthritis patients: a nested diagnostic study within a randomized controlled trial. JACM. 2019; doi:10.1089/acm.2018.0273.
  • Mao JM, Davis RT, Coeytaux R, Hullender-Rubin L, Kong JT, MacPherson H, Napadow V, Schnyer R, Wayne PM, Witt CM, Harris R. Acupuncture for chronic low back pain: recommendations  to medicare/medicaid from the society for acupuncture research. JACM. 2019;25(4):367-369.
  • Zhang Y, Zhang H, Nierhaus T, Pach D, Witt CM, Yi M. Default mode network as a neural substrate of acupuncture: evidence, challenges and strategy. Frontiers in Neuroscience. 2019;13:100. doi: 10.3389/fnins.2019.00100.
  • Witt CM, Vertosick EA, Foster NE, Lewith G, Linde K, MacPherson H, Sherman KJ, Vickers AJ on behalf of Acupuncture Trialists' Collaboration. The effect of patient characteristics on acupuncture treatment outcomes: An individual patient data meta-analysis of 20,827 chronic pain patients in randomized controlled trials. Clin J Pain. 2019;35:428-434.
  • Nierhaus T, Chang Y, Bin L, Shi X, Yi M, Witt CM, Pach D. Somatosensory stimulation with XNKQ acupuncture modulates functional connectivity of motor areas. Front Neurosci. 2019;13:147. doi: 10.3389/fnins.2019.00147.
  • Hughes JG, Lewith G, MacPherson H, Witt CM, Cummings M, Fisher P. Assessment of the quality of reporting in studies of acupuncture for patients with cancer using the STRICTA guidelines. Acupunct Med. 2019. doi: 10.1136/acupmed-2017-011592.


  • Kessler C, Dhiman K, Kumar A, Ostermann T, Gupta S, Morandi A, Mittwede M, Stapelfeldt E, Spoo M, Icke K, Michalsen A, Witt CM. Effectiveness of an ayurveda treatment approach in knee osteoarthritis - a randomized controlled trial. Osteoarthritis & Cartilage. 2018; doi 10.1016/j.joca.2018.01.022.
  • Blödt S, Pach D, Eisenhart-Rothe S, Lotz F, Roll S, Icke K, Witt CM. Effectiveness of app-based self-acupressure for women with menstrual pain compared to usual care: a randomized pragmatic trial. Am J Obstet & Gyn. 2018;218(2):227.e1-227.e9.
  • Witt CM. Training oncology physicians to advise their patients on complementary and integrative medicine. JACM. 2018;24(9):1016-1017.


  • Pach D, Piper M, Lotz F, Reihnhold T, Dombrowski M, Chang Y, Liu B, Blödt S, Rotter G, Icke K, Witt CM. Effectiveness and cost-effectiveness of tuina for chronic neck pain: A randomized controlled trial comparing tuina with a no-intervention waiting list. J Altern Com Med. 2017;DOI: 10.1089/acm.2017.0209.
  • Witt CM, Bartsch HH, Güthlin C, Lampert C, Längler A, Ritter CA, Rostock M, Schildmann J, Weis J, Wilhelm M, Horneber M. Kompetenznetz Komplementärmedizin in der Onkologie (KOKON) - ein wissenschaftlicher Beitrag zur Verbesserung der Versorgung. Forum. 2017;32:416-432.
  • Ostermann J, Witt CM, Reinhold T. A retrospective cost-analysis of additional homeopathic treatment in Germany: long-term economic outcomes. PLOS ONE. 2017;12(9):e0182897.
  • Brinkhaus B, Roll S, Jena S, Icke K, Binting S, Lotz F, Willich SN, Witt CM. Acupuncture in patients with allergic asthma: a randomized pragmatic trial. J Altern Comp. 2017;23(4):268-277.


  • Blödt S, Mittring N, Schützler L, Fischer F, Holmberg C, Horneber M, Stapf A, Witt CM. A consultation training program for physician for communication about complementary medicine with breast cancer patients: a prospective, multi-center, cluster-randomized, mixed-method pilot study. BMC Cancer. 2016;16(1):843.
  • Teut M, Knilli J, Daus D, Roll S, Witt CM. Qigong or Yoga versus no intervention in older adults with chronic low back pain - a randomized trial. J Pain, 2016;17(7):796-805.


  • Witt CM, Ausserer O, Baier S, Heidegger H, Icke K, Mayr O, Mitterer M, Roll S, Spizzo G, Scherer A, Thuile C, Wieser A, Schützler L. Effectiveness of an additional individualized multi-component complementary medicine treatment on health-related quality of life in breast cancer patients: a pragmatic randomized trial. Breast Cancer Res Treat, 2015;149:449-460.
  • Witt CM, Pérard M, Berman B, Berman S, Birdsall TC, Defren H, Kümmel S, Deng G, Dobos G, Drexler A, Holmberg C, Horneber M, Jütte R, Knutson L, Kummer C, Volpers S, Schweiger D. Using the framework of corporate culture in “mergers” to support the development of a cultural basis for integrative medicine – guidance for building an integrative medicine department or service. Patient Preference and Adherence. 2015;9:113-120.


  • MacPherson H, Vertosick E, Lewith G, Linde K, Sherman KJ, Witt CM, Vickers AJ; Acupuncture Trialists' Collaboration. Influence of control group on effect size in trials of acupuncture for chronic pain: a secondary analysis of an individual patient data meta-analysis. PLoS One 2014;9(4):e93739. (Brinkhaus = Collaborator).
  • Fischer FH, Lewith G, Witt CM, Linde K, von Ammon K, Cardini F, Falkenberg T, Fønnebø V, Johannessen H, Reiter B, Uehleke B, Weidenhammer W, Brinkhaus B. High prevalence but limited evidence in complementary and alternative medicine: guidelines for future research. BMC Complement Altern Med 2014;14:46.
  • Schnabel K, Binting S, Witt CM, Teut M. Use of complementary and alternative medicine by older adults - a cross-sectional survey. BMC Geriatr 2014;14:38.
  • Blödt S, Pach D, Kaster T, Lüdtke R, Icke K, Reisshauer A, Witt CM. Qigong versus exercise therapy for chronic low back pain in adults - A randomized controlled non-inferiority trial. European J Pain 2014; doi: 10.1002/ejp.529. [Epub ahead of print].
  • Holmberg C, Karner JJ, Rappenecker J, Witt CM. Clinical trial participants' experiences of completing questionnaires: a qualitative study. BMJ Open 2014;4(3):e004363.
  • Holmberg C, Rappenecker J, Karner JJ, Witt CM. The perspectives of older women with chronic neck pain on perceive effects of qigong and exercise therapy on aging: a qualitative interview study. Clinical Interventions in Aging 2014;9:403-10.
  • Reinhold T, Brinkhaus B, Willich SN, Witt C. Acupuncture in Patients Suffering from Allergic Asthma: Is It Worth Additional Costs? J Altern Complement Med 2014;20:169-77.


  • Stöckigt B, Teut M, Witt CM. CAM Use and Suggestions for Medical Care of Senior Citizens: A Qualitative Study Using the World Cafe Method. Evid Based Complement Alternat Med 2013;2013:951245.
  • Fischer FH, Binting S, Bockelbrink A, Heusser P, Hueck C, Keil T, Roll S, Witt C. The effect of attending steiner schools during childhood on health in adulthood: a multicentre cross-sectional study. PLoS One 2013;8(9):e73135.
  • Adler UC, Krüger S, Teut M, Lüdtke R, Schützler L, Martins F, Willich SN, Linde K, Witt CM. Homeopathy for Depression: A Randomized, Partially Double-Blind, Placebo-Controlled, Four-Armed Study (DEP-HOM). PLoS One 2013;8(9):e74537.
  • Teut M, Schnabel K, Baur R, Kerckhoff A, Reese F, Pilgram N, Berger F, Luedtke R, Witt CM. Effects and feasibility of an Integrative Medicine program for geriatric patients-a cluster-randomized pilot study. Clin Interv Aging 2013;8:953-61.
  • Teut M, Dahler J, Hirschberg U, Luedtke R, Albrecht H, Witt C. Homeopathic drug proving of Okoubaka aubrevillei: a randomised placebo-controlled trial. Trials 2013;14(1):96.
  • Pach D, Yang-Strobel X, Lüdtke R, Roll S, Icke K, Brinkhaus B, Witt CM. Standardized versus Individualized Acupuncture for Chronic Low Back Pain: A Randomized Controlled Trial. Evid Based Complement Alternat Med 2013;2013:125937.
  • Roll S, Reinhold T, Pach D, Brinkhaus B, Icke K, Staab D, Jaeckel T, Wegscheider K, Willich S, Witt C. Comparative effectiveness of homeopathic vs. conventional therapy in usual care of atopic eczema in children: long-term medical and economic outcomes. PlosONE 2013;8:1.
  • MacPherson H, Maschino AC, Lewith G, Foster NE, Witt CM, Vickers AJ; Acupuncture Trialists' Collaboration. Characteristics of acupuncture treatment associated with outcome: an individual patient meta-analysis of 17,922 patients with chronic pain in randomised controlled trials. PLoS One 2013;8(10):e77438. (Brinkhaus = Collaborator).
  • Blödt S, Kuhlmey A, Bartholomeyczik S, Behl C, Betsch F, Brinkhaus B, Frühwald M, Füsgen I, Jansen S, Köppel C, Krüger E, Macher M, Michalsen A, Rapp MA, Riepe MW, Schimpf D, Teut M, Warme B, Warning A, Wilkens J, Witt CM. Dementia in Germany: Results of an interdisciplinary expert workshop. Wien Med Wochenschr 2013;163:536-40.
  • Blödt S, Kuhlmey A, Bartholomeyczik S, Behl C, Betsch F, Brinkhaus B, Frühwald M, Füsgen I, Jansen S, Köppel C, Krüger E, Macher M, Michalsen A, Rapp MA, Riepe MW, Schimpf D, Teut M, Warme B, Warning A, Wilkens J, Witt CM. Dementia in Germany: Results of an interdisciplinary expert workshop. Wien Med Wochenschr. 2013;163:536-40.
  • Blödt S, Schützler L, Huang W, Pach D, Brinkhaus B, Hummelsberger J, Kirschbaum B, Kuhlmann K, Lao L, Liang F, Mietzner A, Mittring N, Müller S, Paul A, Pimpao-Niederle C, Roll S, Wu H, Zhu J, Witt CM. Effectiveness of additional self-care acupressure for women with menstrual pain compared to usual care alone: using stakeholder engagement to design a pragmatic randomized trial and study protocol. Trials 2013;14:99.


  • Flower A, Witt C, Liu J, Ulrich-Merzenich G, Yu H, Lewith G. Guidelines for randomised controlled trials investigating Chinese herbal medicine. J Ethnopharmacol 2012;140(3):550-554.
  • Witt C, Meissner K, Pach D, Thiele C, Luedtke R, Ghadiyali Z, Deter H, Zimmermann-Viehoff F. Stimulation of gastric slow waves with manual acupuncture at acupuncture points ST36 and PC6 - a randomized single blind controlled trial. Neurogastroenterol Motil 2012;24(5):438-445.
  • Vickers A, Cronin A, Maschino A, Lewith G, MacPherson H, Foster N, Sherman K, Witt C, Linde K. Acupuncture for chronic pain: individual patient data meta-analysis. Arch Intern Med 2012;172(19):1444-1453.
  • Huang W, Pach D, Napadow V, Park K, Long X, Neumann J, Maeda Y, Nierhaus T, Liang F, Witt CM. Characterizing acupuncture stimuli using brain imaging with FMRI--a systematic review and meta-analysis of the literature. PLoS One.2012;7(4):e32960.
  • Holmberg C, Brinkhaus B, Witt C. Experts' opinions on terminology for complementary and integrative medicine - a qualitative study with leading experts. BMC Complement Altern Med 2012;12:218.
  • Brinkhaus B, Witt C. Making better doctors – using mind-body medicine skills as a self-care element in medical education at the charité university medical school. Forsch Komplementmed 2012;19:4-6.
    Witt CM, Chesney M, Gliklich R, Green L, Lewith G, Luce B, McCaffrey A, Rafferty Withers S, Sox HC, Tunis S, Berman BM. Building a strategic framework for comparative effectiveness research in complementary and integrative medicine. eCAM 2012;2012:531096.
  • Witt C. Huang W, Lao L, Berman B. Which research is needed to support clinical decision-making on integrative medicine? Can comparative effectiveness research close the gap? Chin J Integr Med 2012;18(10):723-729.


  • Weidenhammer W, Lewith G, Falkenberg T, Fønnebø V, Johannessen H, Reiter B, Uehleke B, von Ammon K, Baumhöfener F, Brinkhaus B. EU FP7 project 'CAMbrella' to build European research network for complementary and alternative medicine. Forsch Komplementmed 2011;18:69-76.
    Rendant D, Pach D, Luedtke R, Reisshauer A, Mietzner A, Willich S, Witt C. Qigong versus exercise versus no therapy for patients with chronic neck pain: a randomized controlled trial. Spine 2011;36(6):419-427.
  • Pach D, Brinkhaus B, Roll S, Wegscheider K, Icke K, Willich S, Witt C. Efficacy of injections with Disci/Rhus toxicodendron compositum for chronic low back pain--a randomized placebo-controlled trial. PLoS One 2011;6(11):e26166.
  • Witt CM, Pach D, Reinhold T, Wruck K, Brinkhaus B, Mank S, Willich SN. Treatment of the adverse effects from acupuncture and their economic impact: a prospective study in 73,406 patients with low back or neck pain. Eur J Pain 2011;15(2):193-7.
  • Brinkhaus B, Witt CM, Jena S, Bockelbrink A, Ortiz M, Willich SN. Integration of complementary and alternative medicine into medical schools in Austria, Germany and Switzerland – results of a cross-sectional study. Wien Med Wochenschr 2011;161:32-43.

2010 and 2009

  • Witt CM, Brinkhaus B. Efficacy, effectiveness and cost-effectiveness of acupuncture for allergic rhinitis – an overview about previous and ongoing studies. Autonomic Neuroscience: Basic and Clinical 2010;157(1-2):42-45.
  • Vickers AJ, Cronin AM, Maschino AC, Lewith G, Macpherson H, Victor N, Sherman KJ, Witt C, Linde K & the Acupuncture Trialists' Collaboration including Brinkhaus B. Individual patient data meta-analysis of acupuncture for chronic pain: protocol of the Acupuncture Trialists' Collaboration.; Acupuncture Trialists' Collaboration. Trials 2010 28;11:90.
  • Witt CM, Brinkhaus B, Willich SN. Future medical doctors need to be informed about CAM to ensure safe and competent patient care. GMS Z Med Ausbild 2010;27:Doc22.
  • Pach D, Knoechel B, Luedtke R, Wruck K, Willich S, Witt C. Visiting a sauna: does inhaling hot dry air reduce common cold symptoms? A randomised controlled trial. Med J Aust 2010;193(11-12):730-734.
  • von Trott P, Wiedemann A, Luedtke R, Reishauer A, Willich S, Witt C. Qigong and exercise therapy for elderly patients with chronic neck pain (QIBANE): a randomized controlled study. J Pain 2009;10(5):501-508.
  • Witt C, Pach D, Brinkhaus B, Wruck K, Tag B, Mank S, Willich S. Safety of acupuncture: results of a prospective observational study with 229,230 patients and introduction of a medical information and consent form. Forsch Komplementärmed Klass Naturheilkd 2009;16(2):91-97.
  • Witt C, Brinkhaus B, Pach D, Reinhold T, Wruck K, Roll S, Jackel T, Staab D, Wegscheider K, Willich S. Homoeopathic versus conventional therapy for atopic eczema in children: medical and economic results. Dermatology 2009;219(4):329-340.
  • Witt C, Reinhold T, Jena S, Brinkhaus B, Willich S. Cost-effectiveness of acupuncture in women and men with allergic rhinitis: a randomized controlled study in usual care. Am J Epidemiol 2009;169(5):562-571.


  • Brinkhaus B, Witt C, Jena S, Liecker B, Wegscheider K, Willich S. Acupuncture in patients with allergic rhinitis: a pragmatic randomized trial. Ann Allergy Asthma Immunol 2008;101(5):535-543.
    Witt C, Linde K. The need of CAM research training. Forsch Komplementärmed Klass Naturheilkd 2008:15:6970.
  • Jena S, Witt C, Brinkhaus B, Wegscheider K, Willich S. Acupuncture in patients with headache. Cephalalgia 2008;28(9):969-979.
  • Witt C, Reinhold T, Jena S, Brinkhaus B, Willich S. Cost-effectiveness of acupuncture treatment in patients with headache. Cephalalgia 2008;28(4):334-345.
  • Reinhold T, Witt C, Jena S, Brinkhaus B, Willich S. Quality of life and cost-effectiveness of acupuncture treatment in patients with osteoarthritis pain. Eur J Health Econ 2008;9(3):209-219.
  • Witt C, Luedtke R, Mengler N, Willich S. How healthy are chronically ill patients after eight years of homeopathic treatment? - Results from a long term observational study. BMC Public Health 2008;8:413.
  • Witt C, Reinhold T, Brinkhaus B, Roll S, Jena S, Willich S. Acupuncture in patients with dysmenorrhea: a randomized study on clinical effectiveness and cost-effectiveness in usual care. Am J Obstet Gynecol 2008;198(2):166 e161-168.
  • Keil T, Witt C, Roll S, Vance W, Weber K, Wegscheider K, Willich S. Homoeopathic versus conventional treatment of children with eczema: a comparative cohort study. Complement Ther Med 2008;16(1):15-21.

2007 and earlier

  • Witt C, Becker M, Bandelin K, Willich SN. Xianggong (`Fragrant`Qigong) for the health of school children: a qualitative pilot study of feasibility and effects. Journal of Chinese Medicine 2007;84:46-51.
  • Witt CM, Jena S, Brinkhaus B, Liecker B, Wegscheider K, Willich SN. Acupuncture in patients with osteoarthritis of the knee or hip. Arthritis & Rheumatism 2006;54(11):3485-3493.
  • Willich SN, Reinhold T, Selim D, Jena S, Brinkhaus B, Witt CM. Cost-effectiveness of acupuncture treatment in patients with chronic neck pain. Pain 2006;125(1-2):107-13.
  • Witt CM, Jena S, Brinkhaus B, Liecker B, Wegscheider K, Willich SN. Acupuncture for patients with chronic neck pain. Pain 2006;125(1-2):98-106.
  • Witt CM, Jena S, Selim D, Brinkhaus B, Reinhold T, Wruck K, Liecker B, Linde K, Wegscheider K, Willich SN. Pragmatic randomized trial evaluating the clinical and economic effectiveness of acupuncture for chronic low back pain. Am J Epidemiol. 2006;164(5):487-96.
  • Witt C, Brinkhaus B, Jena S, Linde K, Streng A, Wagenpfeil S, Hummelsberger J, Walther HU, Melchart D, Willich SN. Acupuncture in patients with osteoarthritis of the knee: a randomised trial. Lancet 2005;366(9480):136-43.
  • Witt C, Keil T, Selim S, Roll S, Vance W, Wegscheider K, Willich SN. Outcome and costs of homeopathic and conventional treatment strategies: A comparative cohort study in patients with chronic disorders. Compl Ther in Med 2005;13:79-86.
  • Witt C, Becker M, Bandelin K, Soellner R, Willich SN. Qigong for schoolchildren: a pilot study. J Altern Complement Med 2005;11:41-47.
  • Witt CM, Lüdtke R, Baur R, Willich SN. Homeopathic medical practice: long-term results of a cohort study with 3981 patients. BMC Public Health 2005;5:115.